Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
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چکیده
منابع مشابه
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2016
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2016.02.043